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The .NET Framework is Microsoft's application development platform that enables developers to easily create Windows applications, web applications, and web services using a myriad of different programming languages, and without having to worry about low-level details like memory management and processor-specific instructions.
This is how Microsoft describes it: “.NET is the Microsoft Web services strategy to connect information, people, systems, and devices through software. Integrated across the Microsoft platform, .NET technology provides the ability to quickly build, deploy, manage, and use connected, security-enhanced solutions with Web services. .NET-connected solutions enable businesses to integrate their systems more rapidly and in a more agile manner and help them realize the promise of information anytime, anywhere, on any device.” See Microsoft for more information.